Sildenafil + Tadalafil (Essential Ignite™)

What is Sildenafil + Tadalafil Used For?

Sildenafil + Tadalafil is a medication used to treat erectile dysfunction (ED) in adult men. It helps improve the ability to achieve and maintain an erection sufficient for sexual activity.

Unlike Sildenafil or Tadalafil standalone oral tablets, Essential Ignite is a specially compounded formulation that combines the active ingredients found in both sildenafil and tadalafil into a single pill, offering a convenient option for those seeking support with erectile function. While it is not currently authorized by Health Canada and is used off-label for the treatment of erectile dysfunction, it is prepared by licensed pharmacists following strict compounding standards. As with any medication, it’s important to consult your healthcare provider to determine if this option is right for you.

How Does Sildenafil + Tadalafil Work?

Sildenafil + Tadalafil is a combination of two phosphodiesterase type 5 (PDE5) inhibitors that increases blood flow to the penis in response to sexual stimulation. This helps achieve and sustain an erection.

How to Take Sildenafil + Tadalafil

Place one tablet under your tongue about 15 to 20 minutes before sexual activity and allow it to dissolve completely.
Do not chew or swallow it whole.
You do not have to take it with water.
Sildenafil + Tadalafil can be taken with or without food.
The effects of Sildenafil + Tadalafil may last up to 36 hours, allowing for greater spontaneity.
Do not take more than one dose within a 36-hour period (Maximum Sildenafil 100mg or Tadalafil 20mg within 24 hours).
Sexual stimulation is required for Sildenafil + Tadalafil to work.
Alcohol consumption can result in greater risk of headaches and flushing.

What If You Miss a Dose?

Sildenafil + Tadalafil is taken as needed, so a missed dose is not typically an issue.
Do not take extra tablets to make up for a missed dose.

Possible Side Effects & What to Watch For

Most people tolerate Sildenafil + Tadalafil well, but some may experience side effects, including:

Common Side Effects:

Headache, flushing, or dizziness.
Nasal congestion.
Indigestion or upset stomach.
Back pain or muscle aches (typically resolves within 48 hours).

Serious Side Effects – Seek Medical Help If You Experience:

Sudden vision or hearing loss.
Chest pain, irregular heartbeat, or shortness of breath.
An erection lasting more than 4 hours (priapism) – this is a medical emergency and requires immediate treatment.

Warnings & Precautions

Do not take Sildenafil + Tadalafil if you use nitrates (such as nitroglycerin) for chest pain, as this can cause a dangerous drop in blood pressure.
Avoid excessive alcohol consumption, as this may increase the risk of side effects.
If you have a history of heart disease, stroke, or low blood pressure, consult your doctor before taking this medication.

Drug Interactions

Avoid taking Sildenafil + Tadalafil with other PDE5 inhibitors (e.g., Vardenafil, Tadalafil as a standalone product, Sildenafil as a standalone product) or medications for pulmonary hypertension.
Certain medications, including some antibiotics, antifungals, and HIV medications, may affect how Sildenafil + Tadalafil works. Inform your healthcare provider of all medications you are taking.
If you are currently taking blood pressure medication, note that this drug may also cause a sudden drop in blood pressure. This can lead to headaches, flushing, dizziness and increase the potential for falls. Please exercise caution. If you have been lying down for a long time, sit up for a few minutes before standing to avoid dizziness.

Storage Instructions

Store at room temperature (15°C - 30°C) in a dry place.
Keep Sildenafil + Tadalafil out of reach of children.

Frequently Asked Questions

Is it safe to combine sildenafil and tadalafil?

Combining these two medications is not generally recommended without medical supervision due to potential risks. However, Ignite is carefully formulated and prescribed by licensed Canadian healthcare professionals who assess your health profile to ensure safety. Clinical studies have indicated that, under proper medical guidance, this combination can be both effective and well-tolerated. https://onlinelibrary.wiley.com/doi/10.1111/and.12216

Can I drink alcohol while taking Essential Ignite?

Moderate alcohol consumption is generally acceptable. However, excessive drinking can diminish the effectiveness of ED medications and increase the risk of side effects like dizziness or lowered blood pressure. It's advisable to limit alcohol intake when using Ignite.

Is Essential Ignite (sildenafil + tadalafil) better than taking Viagra (sildenafil) or Cialis (tadalafil) alone?

Many men appreciate the fast peak effect of sildenafil combined with the long duration of tadalafil, all in a single dose. The sublingual form allows it to absorb even faster. Some evidence suggests this combo may be more effective for men with severe ED or for those who haven’t seen results from either drug alone. Your clinician will help determine if Essential Ignite offers advantages over single-ingredient options for you.

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Portions of this document last updated: May 30, 2025